Figure 1.

Microfluidic device configuration and micrographs of cells. (a) Fabrication and packaging process of our microfluidic device. (b) The cell region is composed of hexagonal arrays of connected microhabitats. Red dotted lines are the microposts separating the cell region from the nutrient- and drug-supplying channels. Drug gradient is constructed from the top to the bottom. (c) Image of cells after applying 6 days of doxorubicin gradient (0–2 µM 2 mm⁻¹). Red, multiple myeloma cells (8226/RFP); green, bone marrow stromal cells (HS-5/GFP).