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. Author manuscript; available in PMC: 2014 Jun 26.
Published in final edited form as: Psychopharmacology (Berl). 2012 Sep 7;224(1):33–56. doi: 10.1007/s00213-012-2853-3

Table 5.

Prosocial interactions occurring within the drug context on drug abuse-related behaviors in rodents

Model Drug Dose Effect Type of social interaction References
Self-administration Amphetamine 0.1 mg/kg, i.v. ↑ amphetamine
  intake
Conspecific behind Plexiglas wall Gipson et al, 2011b
Nicotine 0.015 mg/kg, i.v. ↑ nicotine intake
  (males only)
Conspecific self-administering in chamber
with mesh separating wall
Peartree et al, 2011
0.015 mg/kg, i.v. ↓ nicotine intake
(females only)
Conspecific self-administering in chamber
with mesh separating wall
Peartree et al, 2011
15–30 µg/kg, i.v. ↑ nicotine intake Conspecific self-administering olfactory-
gustatory drug-CS in chamber with
perforated Plexiglas separating wall
Chen et al, 2011
Ethanol* 3–10%, oral ↑ ethanol intake Social-conditioned cue (scent of ethanol on
intoxicated conspecific)
Hunt et al, 2000, 2001;
Maldonado et al, 2008
CPP Methamphetamine 2 mg/kg, i.p. ↑ amphetamine CPP Drug +conspecific US during conditioning Watanabe, 2011 (only if
conspecific is in similar drug
state)
Cocaine 2 mg/kg, i.p. ↑ cocaine CPP Drug +conspecific US during conditioning Thiel et al, 2008
Nicotine 0.1 mg/kg, s.c. ↑ nicotine CPP Drug +conspecific US during conditioning Thiel et al, 2009a
Morphine 0.25–5 mg/kg, s.c. ↑ morphine CPP Drug +conspecific US during conditioning Kennedy et al, 2011 (anti-social
strain of mice)
↓ morphine CPP Drug +conspecific US during conditioning Kennedy et al, 2011 (social
strain of mice)
Ethanol 4 g/kg 20%, oral ↓ ethanol CPA Drug +conspecific US during conditioning Gauvin et al, 1994
CPP-like procedure Ethanol ↑ approach to
  ethanol cue
Social-conditioned cue (scent of ethanol on
intoxicated conspecific)
Fernandez-Vidal & Molina, 2004
*

Choice ethanol consumption