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. 2014 Jun 26;5:309. doi: 10.3389/fpls.2014.00309

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Copyright © 2014 Holm and Vikström.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Human intestinal epithelial cells listen to and act on Pseudomonas aeruginosa 3O-C₁₂-HSL signaling. IQGAP1 is a novel membrane-associated target for 3O-C₁₂-HSL that helps human epithelial cell recognize and response to bacterial QS signaling. Further, 3O-C₁₂-HSL triggers multiple signaling pathways, those include calcium mobilization, activation of Rho GTPases Rac1/Cdc42, MAPK, protein kinases, and protein phosphotases. These can control diverse functions and behaviors in epithelial cells, like cytoskeleton remodeling, migration, wound healing, barrier integrity, and paracellular permeability.