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. Author manuscript; available in PMC: 2015 Jul 1.
Published in final edited form as: Biomaterials. 2014 Apr 19;35(22):5637–5646. doi: 10.1016/j.biomaterials.2014.03.076

Figure 2.

Figure 2

Normalized CD68+ immunoreactivity surrounding implanted intracortical microelectrodes in the rat and the mouse model. (A) Significantly more CD68+ immunoreactivity was observed in the rat model up to 100 μm from the interface at two weeks (solid red) compared to sixteen weeks (dashed red). (B) In the mouse model, both two (solid blue) and sixteen (dashed blue) weeks demonstrated similar intensity expression profiles for CD68. (C) Comparing the percent CD68+ distribution profiles between the rat and mouse model showed no statistical differences for any investigated binning interval at two weeks post implantation. (D) However, the mouse model had significantly higher CD68+ immunoreactivity from 0-50 μm from the implanted device at sixteen weeks compared to the mouse model. *p<0.05; Scale = 100 μm; n = 4-7 animals for each cohort