Table 2.

Epigenetic regulation of type I and type II nuclear receptors

Type	Major receptor	Gene	Methylation control	miRNA control	Related disorders	References
I	Androgen receptor	AR	Yes	U	Prostate; endometrial	Kinoshita et al. (2000) and Sasaki et al. (2000)
	Estrogen receptor 1	ESR1	Yes	miR-206	Breast	Yoshida et al. (2000), Archey et al. (2002), Adams et al. (2007), Champagne & Curley (2008) and Kondo et al. (2008)
	Estrogen receptor 2	ESR2	Yes	U	Prostate; breast; ovary	Zhao et al. (2003), Zhu et al. (2004), Zhang et al. (2007) and Zama & Uzumcu (2009)
	Progesterone receptor	PGR	Yes	U	Endometrial; prostate	Sasaki et al. (2003)
	Glucocorticoid receptor	NR3C1	Yes	miR-124a	Brain disorder; obesity	Vreugdenhil et al. (2009) and Stevens et al. (2010)
	Mineralocorticoid receptor	NR3C2	Yes	miR-124 and -135a	Testes	Martinez-Arguelles et al. (2009) and Sober et al. (2010)
II	Retinoic acid receptor-α	RARA	Yes	U	Leukemia	Chim et al. (2005)
	Retinoic acid receptor-β	RARB	Yes	U	Gastric and esophageal cancer	Hayashi et al. (2001) and Wang et al. (2003)
	Retinoic acid receptor-γ	RARG	U	miR-182	Senescence	Li et al. (2009a)
	Retinoid X receptor-α	RXRA	U	miR-27a and -27b	Liver fibrosis	Ji et al. (2009)
	Retinoid X receptor-β	RXRB	U	U
	Retinoid X receptor-γ	RXRG	U	U
	Thyroid hormone receptor-α	THRA	U	U
	Retinoic acid receptor-β	THRB	U	U

U, unknown or unclear, denotes no or very few papers reported as of 1 August 2010.