Table 4.
Epigenetic regulation of peptide hormone receptor genes
| Hormone |
Receptor gene |
Methylation control |
miRNA control |
Related tissue/cell |
References |
|---|---|---|---|---|---|
| GnRH | GNRHR | U | U | ||
| TRH | TRHR | U | U | ||
| Somatostatin | SSTR1 | U | U | ||
| Vasopressin | AVPR1A | U | U | ||
| Oxytocin | OXTR | Yes | U | Temporal cortex in autism | Gregory et al. (2009) |
| FSH | FSHR | Yes | U | Male gonad | Griswold & Kim (2001) |
| LH | LHCGR | U | U | ||
| TSH | TSHR | Yes | U | Thyroid tumors | Xing et al. (2003) |
| MSH | MC1R | U | U | ||
| GH | GHR | U | U | ||
| Prolactin | PRLR | U | U | ||
| Gastrin | CCKBR | U | U | ||
| Cholecystokinin | CCKAR | U | U | ||
| Secretin | SCTR | U | U | ||
| Insulin | INSR | U | U | ||
| IGF2 | IGF1R/IGF2R | U/yes | miR-223/hsa-miR-657 | Neutrophils/HEK 293 and Hep G2 cells | Stoger et al. (1993), Johnnidis et al. (2008), Lv et al. (2008) and Schayek et al. (2010) |
| Glucagon | GCGR | U | U | ||
| Leptin | LEPR | No | U | Adipose tissue | Noer et al. (2006) |
| Adiponectin | ADIPOR1/ADIPOR2 | U | U |
U, unknown or unclear, denotes no or very few papers reported as of 1 August 2010.