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. 2014 Jun 26;8:121. doi: 10.3389/fnsys.2014.00121

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Copyright © 2014 Gerstner, Smith, Lenz, Perron, Buono and Ferraro.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Diurnal effects on seizure threshold. Endpoints of electroshock-induced seizures for the three light-period groups (ZT1, 5, 9) and dark-period groups (ZT15, 19, 23) show differential percent probability of no response in both (A) generalized (GEST) and (B) maximal (MEST) electroshock seizure threshold, with greater resistance in the dark-phase (solid line) compared to the light phase (dashed line). (A) Median trial number to reach GEST: Light = 10, Dark = 11; Logrank test: Chi-square 11.31, P = 0.0008; N = 18 per group. (B) Median trial number to reach MEST: Light = 22, Dark = 25; Logrank test: Chi-square 13.96, P = 0.0002; N = 18 per group.