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. 2014 Jun 26;8:121. doi: 10.3389/fnsys.2014.00121

Figure 3.

Figure 3

Diurnal seizure susceptibility and baseline setpoint depends on BMAL1 expression. Time-of-day variation in (A) generalized (GEST) and (B) maximal (MEST) electroshock seizure threshold observed in wild-type (WT) mice is blocked in BMAL KO mice. (A) t-test (two-tail) WT GEST: ZT1 vs. ZT15 *p < 0.05; WT vs. BMAL KO GEST: ZT1 vs. ZT1 *p < 0.05, ZT15 vs. ZT15 **p < 0.01. (B) t-test (two-tail) WT MEST: ZT1 vs. ZT15 **p < 0.01; WT vs. BMAL KO GEST: ZT15 vs. ZT15 ***p < 0.001. Error bars = s.e.m. ZT, zeitgeber time.