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. 2014 Jun 26;8:121. doi: 10.3389/fnsys.2014.00121

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Copyright © 2014 Gerstner, Smith, Lenz, Perron, Buono and Ferraro.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Diurnal effects on seizure endpoints are blocked in BMAL1 KO mice. (A) and (B) Endpoints of electroshock-induced seizures for the BMAL KO mice in the light-period (ZT1) and dark-period (ZT15) fail to show differential percent probability of no response in either (A) generalized (GEST) or (B) maximal (MEST) electroshock seizure threshold. (A) Median trial number to reach GEST: Light = 7, Dark = 7; Logrank test, P = 0.9703; N = 6–7 per group. (B) Median trial number to reach MEST: Light = 17, Dark = 18; Logrank test, P = 0.8362; N = 6–7 per group.