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. 2014 Jun 26;8:121. doi: 10.3389/fnsys.2014.00121

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Copyright © 2014 Gerstner, Smith, Lenz, Perron, Buono and Ferraro.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Seizure endpoints are reduced in BMAL1 KO mice compared to WT. (A) and (B) Endpoints of electroshock-induced seizures comparing BMAL KO mice and WT mice from data combined in for the light-period (A, ZT1) and dark-period (B, ZT15) show differential percent probability of no response in both generalized (GEST) and maximal (MEST) electroshock seizure threshold. (A) ZT1, Median trial number to reach GEST: WT = 10, BMAL KO = 7; Logrank test, P = 0.0857; Median trial number to reach MEST: WT = 22, BMAL KO = 17; Logrank test, P = 0.1633, N = 6 per group. (B) ZT15, Median trial number to reach GEST: WT = 13, BMAL KO = 7; Logrank test, P = 0.0023; Median trial number to reach MEST: WT = 26, BMAL KO = 18; Logrank test, P = 0.0005; N = 6–7 per group.