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. 2014 Jun 26;8:234. doi: 10.3389/fnbeh.2014.00234

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Copyright © 2014 Wu, Bai, Tan, Li, Xia, Chang, Zhou, Zhou, Li, Wang, and Dong.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Lithium reduces depressive-like behavior in neonatal isolation rats. In forced swimming paradigm, both latency to immobility (A) and struggling time during the last 4 min (B) are significantly reduced in isolated rats compared to control, and lithium treatment recovers the impairment. Two-way ANOVA analysis was used in this experiment. For latency to immobility: treatment × drug, F_{(1, 95)} = 9.779 P < 0.05; treatment, F_{(1, 95)} = 19.003, P < 0.05; drug, F_{(1, 95)} = 3.473, P > 0.05. For time in struggling: treatment × drug, F_{(1, 95)} = 1.178, P > 0.05; treatment, F_{(1, 95)} = 3.968, P < 0.05; drug, F_{(1, 95)} = 3.648, P > 0.05. Data show mean ± SEM (*p < 0.05; **p < 0.01).