Table 3.
First author |
Year |
Genotypes distribution (Case source) |
Genotypes distribution (Controls source) |
P-HWE (Controls) |
T2T2 versus T1T1 | T1T2 versus T1T1 | T1T2+T2T2 versus T1T1 | T2T2 versus T1T1+T1T2 | ||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
T1T1 | T1T2 | T2T2 | T1T1 | T1T2 | T2T2 | OR (95% CI) | P | OR (95% CI) | P | OR (95% CI) | P | OR (95% CI) | P | |||
Auranen [20] | 2005 | 676 | 762 | 227 | 1712 | 1946 | 583 | Yes | 0.99 [0.83, 1.18] | 0.88 | 0.99 [0.88, 1.12] | 0.89 | 0.99 [0.88, 1.11] | 0.87 | 0.99 [0.84, 1.17] | 0.91 |
Beesley [26] | 2007 | 291 | 339 | 101 | 288 | 351 | 108 | Yes | 0.93 [0.67, 1.27] | 0.63 | 0.96 [0.77, 1.19] | 0.69 | 0.95 [0.77, 1.17] | 0.62 | 0.95 [0.71, 1.27] | 0.72 |
Quaye [25] | 2009 | 545 | 612 | 175 | 784 | 958 | 282 | Yes | 0.89 [0.72, 1.11] | 0.31 | 0.92 [0.79, 1.07] | 0.27 | 0.91 [0.79, 1.05] | 0.21 | 0.93 [0.76, 1.14] | 0.51 |
Webb [27] | 2005 | 591 | 656 | 198 | 307 | 375 | 106 | Yes | 0.97 [0.74, 1.28] | 0.83 | 0.91 [0.75, 1.10] | 0.32 | 0.92 [0.77, 1.10] | 0.37 | 1.02 [0.79, 1.32] | 0.87 |
| ||||||||||||||||
Total | 2103 | 2369 | 701 | 3091 | 3630 | 1079 | 0.95 [0.85, 1.06] | 0.37 | 0.95 [0.88, 1.03] | 0.22 | 0.95 [0.88, 1.02] | 0.19 | 0.97 [0.88, 1.08] | 0.63 | ||
Test for
heterogeneity |
P = 0.91 |
Test for
heterogeneity |
P = 0.88 |
Test for
heterogeneity |
P = 0.82 |
Test for
heterogeneity |
P = 0.77 |