Table 2.
Literature analysis.
| Publication | Animal/number/group | Defect size/time of study | Implant | Bone volume in % |
|---|---|---|---|---|
| [38] | Rabbit/n = 10 | 15 mm/12 weeks | Empty | 24.4 |
| Autologous bone | 82 | |||
| Empty + Lactosorb | 23.9 | |||
| DBM + Lactosorb | 84 | |||
| CPC | 13.1 | |||
| CPC + BMP | 45.8 | |||
|
| ||||
| [39] | Rabbit/n = 10 | 6 mm | Ca-P | 17 |
| 6 mm | Empty | n.a. | ||
| 9 mm | Ca-P | 18 | ||
| 9 mm | Empty | n.a. | ||
| 15 mm | Ca-P | 17 | ||
| 15 mm/12 weeks | Empty | n.a. | ||
|
| ||||
| [40] | Rabbit/n = 9 (4 defects/rabbit) |
6 mm/4 weeks | PLGA | 25.1 |
| PLGA/TCP | 34.9 | |||
| BioOss | 30.8 | |||
| empty | 28.4 | |||
|
| ||||
| [41] | Rabbit/n = 33 | 6 mm/12 weeks | Polycaprolactone-TCP | 32 |
| 24 weeks | Polycaprolactone-TCP | 25 | ||
|
| ||||
| [42] | Rabbit/n = 16 | 6 mm | 6 mm empty | 53.6 |
| 8 mm | 8 mm empty | 41.8 | ||
| 11 mm | 11 mm empty | 35.1 | ||
| 15 mm/12 weeks | 15 mm empty | 20.1 | ||
|
| ||||
| [43] | Rabbit/n = 4/5 | 15 mm/6 weeks | TyrPC | 16 |
| TyrPC + rhBMP-2 | 34 | |||
| TyrPC + CP | 4 | |||
| BGS | 4 | |||
|
| ||||
| [44] | Rabbit/n = 10 | 15 mm/12 weeks | CPC | 14 |
| BC | 21 | |||
| Empty | 17.5 | |||
| 6 weeks | BC + rh rhBMP-2 | 27 | ||
|
| ||||
| [45] | Rabbit/n = 4 for mPCL and empty, n = 6 for mPCL + BMPC and OB |
15 mm/3 months | m-polycaprolactone | n.a. |
| m-polycaprolactone + BMPC | 4.7 | |||
| m-polycaprolactone + cOB | 4.7 | |||
| empty | n.a. | |||
| 12 months | m-polycaprolactone | 1.2 | ||
| m-polycaprolactone + BMPC | 12.5 | |||
| m-polycaprolactone + cOB | 12.5 | |||
| empty | 1.2 | |||
DBM + Lactosorb (demineralized bone matrix), CPC (calcium phosphate cement), CPC + BMP (calcium phosphate cement + bone morphogenetic protein); Ca-P (calcium phosphate); PLGA (poly(lactide-coglycolide)), PLGA/TCP (PLGA/tricalcium phosphate), BioOss (bovine derived mineral); polycaprolactone-TCP (polycaprolactone-tricalcium phosphate); TyrPC (tyrosine-derived polycarbonate), TyrPC + rhBMP-2 (TyrPC + recombinant human bone morphogenetic protein-2), TyrPC + CP (TyrPC + calcium phosphate), BGS (bovine type-I collagen + tricalcium phosphate); CPC (calcium phosphate cement), BC (biocomposite = lysine derived polyurethane and allograft), BC + rhBMP-2 (BC + recombinant human bone morphogenetic protein-2); m-polycaprolactone (medical grade polycaprolactone), m-polycaprolactone + BMPC (m-polycaprolactone + bone marrow derived mesenchymal progenitor cells), m-polycaprolactone + cOB (m-polycaprolactone + calvarial osteoblasts).