Table 2. Inhibition of cell–cell fusion by PBDK–sphing, PBDK and sphinganine.
Inhibition of cell–cell fusion: TZM-bl target cells were mixed with HL2/3 effector cells in the presence of different compounds. IC50 (concentration achieving 50% inhibition of infection) and IC90 (concentration achieving 90% inhibition of infection) values for each compound were calculated via luciferase expression as described in the Materials and methods section.
| Designation | IC50 (μM) | IC90 (μM) |
|---|---|---|
| Sphinganine | >1.5 | >14 |
| PBDK | >1.5 | >14 |
| PBDK–sphing | 0.88±0.07 | 2.24±0.75 |