Figure 2.

Multivariate analysis (volcano plot) of all common metabolites measured on the Metabolon platform and their association with progression to ESRD are demonstrated as a fold difference (x axis) and significance adjusted for multiple comparisons and presented as q values (y axis). Uremic solutes comprise metabolites of interests in Figure 2A, amino acids are metabolites of interests in Figure 2B. Uremic solutes are not displayed in Figure 2B. Common and stable metabolites of interest are represented as red circles (), common, but not stable over time as red empty circles (), all other common as grey circles (). Blue circles represent essential amino acids ().