Table 2. Pharmacokinetic Parameters Derived from Noncompartmental Analysis of ³H-Liposomes Injected into CD-1 Mice^a.

formulation	t1/2 (h)	AUC0-∞ (%ID·h/mL)	Vd (mL)	CL (mL/h)	MRT (h)
5–8 kDa HA	6.32 ± 0.69	327 ± 53	2.87 ± 0.77	0.31 ± 0.05	8.7 ± 0.6
50–60 kDa HA	7.35 ± 0.75	324 ± 34	3.28 ± 0.21	0.31 ± 0.03	9.6 ± 1.0
175–350 kDa HA	9.14 ± 1.64	216 ± 34*	6.14 ± 0.98**	0.47 ± 0.07*	11.5 ± 3.1
mPEG-5000	9.60 ± 2.46	428 ± 8*	3.23 ± 0.78	0.23 ± 0.01	11.5 ± 3.3

^aAll values are reported as mean ± SD. AUC_0-∞ values were calculated by using trapezoidal integration of radioactivity concentrations (%ID/mL blood) versus time curves from 0 to 24 h and extrapolation from 24 h to infinity. Statistical analyses among HA-liposomes and PEGylated liposomes were conducted using one-way ANOVA followed by Tukey’s multiple comparison test. *p < 0.05; **p < 0.01 significant difference compared to all other groups.