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. 2014 May 18;9:11. doi: 10.1186/1749-8104-9-11

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Copyright © 2014 Bhansali et al.; licensee BioMed Central Ltd.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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The density of Zic2⁺retinal ganglion cells, but not their distribution, is changed at embryonic day 15.5 in the albino retina. (A) Cartoon depicting the method for counting Zic2⁺ retinal ganglion cells (RGCs) in 75 μm sectors from the periphery towards the center of the ventrotemporal (VT) retina. V, ventral; T, temporal. Black dots represent Zic2⁺ RGCs and dotted lines represent delineations of sectors. (B) Fluorescent images of retinal flat mounts immunostained with a Zic2 antibody at embryonic day 15.5. Zic2 is expressed in VT RGCs. (C) The number of Zic2⁺ cells in each sector of pigmented (n = 6) and albino (n = 6) VT retinae. In each sector, the number of Zic2⁺ cells is lower in albino compared to pigmented retina. However, the peak and distribution of Zic2⁺ cells are similar in the pigmented and albino retina. (D) The area of retinal flatmount does not differ in the pigmented (n = 11) and albino (n = 9) eyes at embryonic day 15.5. For area measurements, 1 pixel = 4.2734 μm². Error bars indicate SEM. Two-tailed unpaired t-test: *P < 0.05, **P < 0.01.