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. 2014 Jun 26;10(6):e1003677. doi: 10.1371/journal.pcbi.1003677

Figure 8. A novel cranial nerve enhancer in the ZEB2 locus.

Figure 8

This UCSC Genome Browser snapshot shows a dense region of predicted enhancers in a 1.5ZEB2 and part of the adjacent gene desert. Tracks give the locations of four human accelerated regions (HARs), two validated VISTA enhancers (hs407 and hs1802), and the E1 region recently shown to have postnatal enhancer activity [87]. The inset shows a zoomed in view of ZEB2 (hg19.chr2:145,100,000–145,425,000) along with summaries of several ENCODE functional genomics datasets and evolutionary conservation across placental mammals. We tested the predicted enhancer overlapping 2xHAR.240 for enhancer activity at E11.5 in transgenic mice. Both the human and chimp versions of this sequence drive consistent expression in the cranial nerve (Figure S11).