Figure 4. System diagram of cellular processes.

Periosteally mediated bone regeneration following mechanical strain stimulus of progenitor cells located in the periosteum, mediated by expression of, e.g. BMP-2. For the purposes of the current model as a foundation for next generation models, BMP is an isolated representative factor implicated in regulating all of the described processes and as such represents a class of signaling molecules whose mechanistic roles can be probed explicitly in follow on studies.