Table 2. Estimated standard deviation and bias in PRNT75 estimates using the different models.
Model | Proportion of assays | Variance (log10 scale) | Bias (log10 scale) |
[95% confidence interval] | |||
Probit regression | 100% | 0.036 [0.030–0.040] | 0.042 [0.035–0.049] |
Logistic regression | 100% | 0.036 [0.030–0.040] | 0.055 [0.049–0.063] |
Cloglog regression | 100% | 0.025 [0.021–0.030] | 0.027 [0.021–0.033] |
Four-parameter non-linear regression | 63% | 0.022 [0.017–0.027] | 0.059 [0.052–0.066] |
Values are averages from the different viruses and serum pools, weighted by the number of experiments.