Skip to main content
. 2014 Jun 26;10(6):e1004435. doi: 10.1371/journal.pgen.1004435

Figure 4. Functional conservation and divergence of unc-47 regulation.

Figure 4

(A) Vista plots represent primary sequence conservation in the intergenic region upstream of unc-47, relative to C. elegans. Window size = 20 bp, threshold: 70%. From top to bottom: C. briggsae, C. remanei, C. brenneri, C. japonica. (B) Expression patterns driven by the C. elegans (Cel), C. briggsae (Cbr), C. remanei (Cre), C. brenneri (Cbn), and C. japonica (Cja) CREs of unc-47. For all cells, frequency of expression is indicated, except for D-type neurons for which the median number of expressing cells in shown. For groups of multiple cells, percentages represent frequency of expression in at least one of these cells: RMEs (RMED/V/L/R), SIADs (SIADL/R), CEPs (CEPD/V L/R), SDQs (SDQL/R), PVNs (PVNL/R). It is unclear whether expression in the SIADs is endogenous [56], [57], [68]. However, since it is consistently seen with the C. elegans CRE, we included it in the endogenous pattern. We classified the strong expression of the C. briggsae unc-47 CRE in SDQL/R as ectopic, even though weak SDQR expression was observed with the C. elegans CRE, because of the dramatic differences in the frequency and intensity of expression [22]. Reduction and losses of expression compared to the endogenous pattern are circled. Detailed data are shown in Table S5.