Figure 7. Estimates of α due to temporally fluctuating recombination rates and variable BGS effects.

Results based on forward population genetic simulations of 10,000 diploid individuals (N), a chromosome segment of 1 Mb containing 100 genes, and two types of mutations: neutral and deleterious (see Materials and Methods for details). Cycles of fluctuating recombination followed phases of moderately high recombination for 1N generations (H _rec phase) and moderately low recombination for 3N generations (L _rec phase). Estimates of α at negatively selected sites obtained following the models proposed by Eyre-Walker and Keightley [91], [95] every 0.1N generations. Blue and red lines indicate estimates of α assuming constant population size and variable population sizes, respectively. Continuous and dashed lines indicate estimates of α with and without correction for the effect of polymorphism to divergence, respectively.