Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2014 Jul 1;25(13):2061–2070. doi: 10.1091/mbc.E13-10-0582

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© 2014 Williams et al. This article is distributed by The American Society for Cell Biology under license from the author(s). Two months after publication it is available to the public under an Attribution–Noncommercial–Share Alike 3.0 Unported Creative Commons License (http://creativecommons.org/licenses/by-nc-sa/3.0).

“ASCB®,” “The American Society for Cell Biology®,” and “Molecular Biology of the Cell®” are registered trademarks of The American Society of Cell Biology.

PMC Copyright notice

FIGURE 8: — A model for MT1-MMP trafficking to invadopodia. MT1-MMP localizes to the late endosomal compartment, characterized by VAMP7, and is targeted to invadopodia, where it functions to degrade the extracellular matrix. 1) VAMP7 is located on MT1-MMP–containing vesicles, and Syntaxin4 and SNAP23 are on the target membrane (site of invadopodium formation). 2) Syntaxin4 associates with SNAP23; this correlates with dephosphorylation of Syntaxin4. 3) The SNAP23-Syntaxin4 complex can bind VAMP7, facilitating membrane fusion and 4) delivery of MT1-MMP to forming invadopodia.