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. 2014 Jun 26;10(6):e1004439. doi: 10.1371/journal.pgen.1004439

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© 2014 Moradigaravand et al

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.

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A) An example of the log fitness plot against the Hamming distance between the reference sequence and sequences at generation 100 of one simulation for 20000 data points. Each point corresponds to one fitness value. To improve the visualization of the data on x axis, random values taken from a normal distribution with mean 0 and standard deviation 0.1 are added to the Hamming distances. The curvature of the red curved fitted to the data points defines population epistasis, which in this example is −0.0405. B) Distribution of population epistasis values across 500 simulations in the absence (blue) and presence (red) of recombination measured at generation 100. Parameters take values: and .

Inline graphic — A) An example of the log fitness plot against the Hamming distance between the reference sequence and sequences at generation 100 of one simulation for 20000 data points. Each point corresponds to one fitness value. To improve the visualization of the data on x axis, random values taken from a normal distribution with mean 0 and standard deviation 0.1 are added to the Hamming distances. The curvature of the red curved fitted to the data points defines population epistasis, which in this example is −0.0405. B) Distribution of population epistasis values across 500 simulations in the absence (blue) and presence (red) of recombination measured at generation 100. Parameters take values: and .