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. Author manuscript; available in PMC: 2014 Jun 26.
Published in final edited form as: J Clin Exp Ophthalmol. 2012 Jan 27;3:208. doi: 10.4172/2155-9570.1000208

Figure 2.

Figure 2

p-STAT3 levels in human eye tissue visualized with Vector Blue (blue) and counterstained with neutral red (pink). (A) Cells (arrows) in the ganglion cell layer (GCL), inner nuclear layer (INL), and outer nuclear layer are found to be immunoreactive (vector blue) for phosphorylated (activated) STAT3 in the older group (≥ 70 yr). (B) Similarly, immunolabeling profile is seen in eyes with drusen ≥ 25 μm regardless of age. Scale bar 30 μm. p-STAT3 accumulation significantly differs (p ≤ 0.05, black asterisk) in the retinal layers between the analyzed groups. STAT3 activation is greater in older eyes (C, ≥ 70 yr, n = 14), in eyes with clinically significant drusen (D, ≥ 25 μm, n = 14) and particularly in eyes with large drusen (F, ≥ 63 μm, n = 10). In the younger group (E, ≤ 57 yr, n = 14), the presence of drusen ≥ 4 μm (n = 7) is associated with increased STAT3 activation compared to eyes without drusen (n = 7).