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. 2014 Jun 26;9(6):e100560. doi: 10.1371/journal.pone.0100560

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© 2014 Alcalde et al

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.

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A- Representation of wild type PKP2. It has HR2 domain and armadillo repeats domain (8 armadillo repeats, ARM). B- Representation of truncated PKP2 (PKP2^TR) and their domains. PKP2^TR p.92* and p.V202Vfs215* only have HR2 domain but not any of ARM repeats, p.R413* loses partially ARM 3 to C-terminus, and p.548fs562* loses partially ARM 4, p.Q638* conserve completely ARM 4 but loses the rest of protein until to C-terminus and p.R735* loses partially ARM6 to C-terminus. PKP2^TR p.K859V*881ent*48 extends their length to 930 amino acids.