Figure 1. The overall representation of our network model.

There are three modules in the network. These modules are connected by two distinctive forms of β-catenin. In additional to the normal form of β-catenins, a second form, active β-catenin, is presented in our model. Only the active β-catenins can activate the gene expression. The activated genetic pathways further affect expressions of proteins in both cadherin adhesion and β-catenin degradation modules through genetic feedback loops. The interplay between Wnt signaling and cell adhesion is captured by inter-module crosstalk, which are labeled with numbers.