Table 3. Association of rs3737884 and rs16850797 with diseases stratified by CAD or T2D status.
| Additive model | Unadjusted | Adjusted | |||
| Comparisons | MM vs. Mm vs. mma | OR(95%CI)b | P b | OR (95%CI)c | P c |
| rs3737884 | |||||
| T2D | 98/62/5 | 1.00(reference) | - | 1.00(reference) | - |
| T2D+CAD | 111/57/6 | 1.14(0.78–1.67) | 0.509 | 1.12(0.74–1.71) | 0.587 |
| CAD | 114/53/6 | 1.00(reference) | - | 1.00(reference) | - |
| T2D+CAD | 111/57/6 | 0.93(0.64–1.37) | 0.726 | 0.91(0.60–1.39) | 0.655 |
| rs16850797 | |||||
| T2D | 8/89/63 | 1.00(reference) | - | 1.00(reference) | - |
| T2D+CAD | 28/73/73 | 1.22(0.88–1.703) | 0.234 | 1.30(0.90–1.89) | 0.163 |
| CAD | 13/64/96 | 1.00(reference) | - | 1.00(reference) | - |
| T2D+CAD | 28/73/73 | 1.62(1.19–2.22) | 0.003 | 1.49(1.05–2.10) | 0.024 |
CAD, coronary artery disease; T2D, type 2 diabetes; T2D+CAD, T2D with CAD; OR, odds ratios; CI, confidence interval.
a
M/m represent G/A for rs3737884, and C/G for rs16850797.
b
unadjusted for gender, age and body mass index;
c
adjusted for gender, age and body mass index. Statistical significances are considered as P≤0.05. ORs are computed using T2D or CAD as the reference group. All OR and P values are obtained by unconditional logistic regression.