Table 4. Cumulative effect analyses of rs3737884 and rs16850797 in ADIPOR1 associated with risk of T2D, CAD and T2D with CAD.
| Number of risk alleles | T2D (N = 160a), n(%) | Control (N = 145), n(%) | OR(95%CI) | P | P trend |
| ≤1 | 36(22.50) | 65(44.83) | 1.00(reference) | - | - |
| 2 | 59(36.88) | 40(27.59) | 2.66(1.50–4.72) | 6.09×10−4 | - |
| ≥3 | 65(40.63) | 40(27.59) | 2.93(1.67–5.17) | 1.64×10−4 | 1.79×10−4 |
| Number of risk alleles | CAD (N = 173), n(%) | Control (N = 145), n(%) | OR(95%CI) | P | P trend |
| ≤1 | 38(21.97) | 65(44.83) | 1.00(reference) | - | - |
| 2 | 79(45.67) | 40(27.59) | 3.38(1.95–5.87) | 1.14×10−5 | - |
| ≥3 | 56(32.37) | 40(27.59) | 2.40(1.35–4.23) | 0.002 | 0.002 |
| Number of risk alleles | T2D+CAD (N = 174), n(%) | Control (N = 145), n(%) | OR(95%CI) | P | P trend |
| ≤1 | 38(21.84) | 65(44.83) | 1.00(reference) | - | - |
| 2 | 57(32.76) | 40(27.59) | 2.44(1.38–4.31) | 0.002 | - |
| ≥3 | 79(45.40) | 40(27.59) | 3.38(1.95–5.87) | 1.14×10−5 | 1.35×10−5 |
Risk alleles are rs3737884, G and rs16850797, C, respectively. CAD, coronary artery disease; T2D, type 2 diabetes; T2D+CAD, T2D with CAD; OR, odds ratios; CI, confidence interval. OR values are calculated using those carrying one or no risk alleles as the reference group. OR and P values are obtained by Pearson’s χ2; P trend, P-value for trend is obtained by performing a χ2 test for linear trend in EpiInfo version 6; All OR, P and P trend values are unadjusted for gender, age and body mass index; Statistical significances are considered as P≤0.05. aNumbers of patients with T2D vary because of missing genotype data.