Table 3. Case-control studies of Prothrombin 20120 G-A Polymorphism and Severe Preeclampsia.
| study | country | ethnicity | cases | controls | OR | 95%CI | ||
| GG | GA/AA | GG | GA/AA | |||||
| Kupferminc(1999) | Israel | Caucasian | 32 | 2 | 107 | 3 | 2.23 | (0.36–13.93) |
| Kupferminc(2000) | Israel | Caucasian | 58 | 5 | 122 | 4 | 2.63 | (0.68–10.16) |
| Kupferminc(2000) | Israel | Caucasian | 50 | 5 | 151 | 5 | 3.02 | (0.84–10.86) |
| Livingston(2001)a | US | 60% African American | 110 | 0 | 96 | 1 | 0.29 | (0.01–7.23) |
| Alfirevic(2001)b | UK | 90% Caucasian | 61 | 2 | 42 | 2 | 0.69 | (0.09–5.08) |
| Tempfer(2004) | Austria | Caucasian | 23 | 1 | 23 | 1 | 1.00 | (0.06–16.97) |
| Koleva(2005) | Bulgaria | Caucasian | 36 | 3 | 99 | 4 | 2.06 | (0.44–9.67) |
| Gerhardt(2005) | German | Caucasian | 93 | 4 | 271 | 6 | 1.94 | (0.54–7.04) |
| Mello(2005) | Italy | Caucasian | 362 | 44 | 398 | 8 | 6.05 | (2.81–13.02) |
| Demir(2006) | Turkey | Caucasian | 29 | 5 | 95 | 7 | 2.34 | (0.69–7.93) |
| Seremak-Mrozikiewicz 2010) | Poland | Caucasian | 63 | 5 | 395 | 5 | 6.27 | (1.76–22.28) |
| Malek-Khosravi(2012) | Western Iran | Caucasian | 68 | 2 | 98 | 3 | 0.96 | (0.16–5.90) |
| Pooled(M-H) | 3.02 | (2.06–4.45) | ||||||
Q = 11.65, p = 0.39, I2 = 5.8%.
a: 60% of the cases were African American, 40% were white Caucasian;
b: 90% of the cases were Caucasian and 10% were non-Caucasian.