Figure 2. A schematic overview of two major protein-coding transcripts of the DNMT3A gene.

The numbered blocks are exons, the connecting lines introns. Genetic variability in DNMT3A mainly occurs in intronic regions while the exonic regions are very well conserved. The dashed line indicates the location of the tagSNP rs11683424, which we found to significantly moderate the association between daily stressful events and negative affect. The DNMT3A2 transcript seems to be regulated by an alternative promoter upstream of exon 7, and bears a unique untranslated exon 4 kb upstream of exon 7 (termed exon 7a). rs11683424 is situated upstream of the DNMT3A2 transcription start site. Gene structure and names of the protein coding transcripts were derived from the Ensembl database (www.ensembl.org).