Table 3. Two-way interaction analyses between SNPs and daily stressful life events in models of NA.
| Step 1 | Step 2 | Step 3 | ||||
| SNP(Gene) | Sample I | Sample II | Sample III | Sample IV | Sample V | |
| rs11683424( DNMT3A ) | CC | a0.1727 b(82) | 0.1762 (312) | 0.1501 (62) | 0.1807 (73) | 0.3008 (78) |
| c(0.1502, 0.1953) | (0.1606, 0.1918) | (0.1238, 0.1764) | (0.1454, 0.2160) | (0.2678, 0.3338) | ||
| CT/TT | 0.0773 (30) | 0.1355 (116) | 0.1653 (23) | 0.1442 (37) | 0.2475 (48) | |
| (0.0384, 0.1161) | (0.1072, 0.1637) | (0.1175, 0.2131) | (0.0996, 0.1887) | (0.2061, 0.2888) | ||
| d P = 0.0000 | P = 0.0133 | P = 0.5848 | P = 0.2075 | P = 0.0482 | ||
| rs1465764( DNMT3A ) | AA | 0.1384 (99) | 0.1758 (367) | 0.1675 (72) | 0.1711 (95) | 0.2734 (109) |
| (0.1178, 0.1590) | (0.1612, 0.1904) | (0.1429, 0.1921) | (0.1422, 0.2000) | (0.2458, 0.3011) | ||
| AT/TT | 0.2374 (13) | 0.1023 (62) | 0.0534 (13) | 0.1109 (14) | 0.3250 (17) | |
| (0.1771, 0.2975) | (0.0650, 0.1396) | (–0.0123, 0.1191) | (0.0100, 0.2117) | (0.2536, 0.3963) | ||
| P = 0.0022 | P = 0.0003 | P = 0.0014 | P = 0.2602 | P = 0.1863 | ||
| rs1465825( DNMT3A ) | TT | 0.1238 (65) | 0.1811 (263) | 0.1671 (51) | 0.1576 (54) | 0.3040 (74) |
| (0.0992, 0.1483) | (0.1634, 0.1988) | (0.1366, 0.1976) | (0.1173, 0.1978) | (0.2693, 0.3386) | ||
| TC/CC | 0.1912 (47) | 0.1447 (166) | 0.1356 (34) | 0.1749 (56) | 0.2505 (52) | |
| (0.1592, 0.2232) | (0.1235, 0.1658) | (0.1004, 0.1708) | (0.1367, 0.2130) | (0.2118, 0.2891) | ||
| P = 0.0010 | P = 0.0097 | P = 0.1851 | P = 0.5410 | P = 0.0433 | ||
| rs2424913( DNMT3B ) | CC | 0.1955 (47) | 0.1564 (142) | |||
| (0.1629, 0.2281) | (0.1335, 0.1794) | |||||
| CT/TT | 0.1227 (65) | 0.1736 (275) | ||||
| (0.0983, 0.1469) | (0.1565, 0.1907) | |||||
| P = 0.0004 | P = 0.2404 | |||||
| rs1801131( MTHFR) | AA | 0.1727 (64) | 0.1814 (211) | 0.1374 (39) | 0.1831 (54) | 0.2847 (64) |
| (0.1502, 0.1953) | (0.1622, 0.2006) | (0.1008, 0.1740) | (0.1414, 0.2247) | (0.2486, 0.3207) | ||
| AC/CC | 0.1142 (48) | 0.1355 (216) | 0.1642 (46) | 0.1559 (55) | 0.2756 (62) | |
| (0.0857, 0.1427) | (0.1331, 0.1715) | (0.1344, 0.1938) | (0.1185, 0.1932) | (0.2387, 0.3125) | ||
| P = 0.0010 | P = 0.0360 | P = 0.2650 | P = 0.3401 | P = 0.7314 | ||
Sample I = Healthy control; Sample II = Twins from the general population; Sample III = Unaffected siblings of psychotic patients; Sample IV = Patients with psychotic disorder; Sample V = Patients with a history of a major depressive disorder currently displaying residual depressive symptoms.
a
Regression coefficient indicates changes in negative affect associated with changes in subjectively appraised stress,
b
number of subject per genotype,
c
95% confidence interval,
d
P-value for the interactive effect model.