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. 2014 Jun 26;9(6):e101005. doi: 10.1371/journal.pone.0101005

Figure 3. Proliferation and apoptosis.

Figure 3

A Representative islets showing insulin (red) and Ki67 (green, indicated by arrows), insulin (red) and TUNEL (green, indicated by arrows) immunoreactivity from C57BL/6, GLP-1RKO and GIPRKO mice. B – Beta cell apoptosis frequency (% of beta cells analysed). C – Beta cell proliferation frequency (% of beta cells analysed). D – Ki67/TUNEL ratio. Values are mean ± SEM of 6 observations unless otherwise indicated. Δp<0.05, ΔΔp<0.01, ΔΔΔp<0.001 compared to respective controls. *p<0.05, **p<0.01, ***p<0.001 compared to respective treatment of C57BL/6 mice.