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. 2014 Jun 26;9(6):e101005. doi: 10.1371/journal.pone.0101005

Figure 4. Glucagon and GLP-1 colocalization.

Figure 4

A Representative islets showing glucagon (green) and GLP-1 (red) immunoreactivity from C57BL/6, GLP-1RKO and GIPRKO mice. Dotted arrows indicate alpha cells expressing mainly of GLP-1 while block arrows indicate colocalization with glucagon (yellow). B – Islets with GLP-1 positive alpha cells (% of total number of alpha cells analysed). C – GLP-1/Glucagon colocalization (Pearson’s colocalization coefficient). Values are mean ± SEM of 6 observations unless otherwise indicated. ΔΔp<0.01, ΔΔΔp<0.001 compared to respective controls. *p<0.05, **p<0.01 compared to respective treatment of C57BL/6 mice.