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. 2014 Jun 26;9(6):e101015. doi: 10.1371/journal.pone.0101015

Figure 3. cJun/cJun homodimers, but not cJun/cFos heterodimers make extensive contacts with aptamer-19.

Figure 3

A) Both cJun/cJun and cJun/cFos protect a discrete region surrounding the AP-1 site on a 78nt long dsDNA construct from DNase I digestion. The relative intensities of the digested products are plotted corresponding to nucleotide position. The digestion profile is presented in the absence of protein (solid gray), in the presence of 10 nM cJun/cJun (blue line), or the presence of 10 nM cJun/cFos (red line). B) cJun/cJun broadly protects aptamer-19 from DNase I digestion, while cJun/cFos does not. C) Digestion profile of aptamer-19 upon hydroxyl radical cleavage in the absence (solid gray) or presence of 5 nM cJun/cJun (blue line).