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. 2014 Jun 26;9(6):e101260. doi: 10.1371/journal.pone.0101260

Figure 3. Effect of free and encapsulated bisphosphonates on human macrophage cultures.

Figure 3

Count of adherent and non-adherent macrophages by Trypan Blue staining after 48 h, 6 days and 14 days after removal of drugs. Results are mean ± SD of at least 3 experiments performed in duplicate. CTL = controls; Lip = empty liposomes; C-lip 0.01, 0.1 mM = Clodronate-liposomes at 0.01 and 0.1 mM concentration, respectively; Zol 0.1 mM = Zoledronate at 0.1 mM concentration; UL = unloaded RBCs; L-Zol = RBCs loaded with Zoledronate to a final concentration of 7.96±2.03 µmoles/ml of packed RBCs. *** p<0.001, **p<0.01 and *p<0.05. by ANOVA analysis with Bonferroni post-hoc test.