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. Author manuscript; available in PMC: 2015 Jul 1.
Published in final edited form as: FEMS Microbiol Rev. 2014 Jan 16;38(4):698–719. doi: 10.1111/1574-6976.12057

Fig. 4. Regulation of PSMs by Agr.

Fig. 4

The Agr quorum-sensing circuit, as described in the text, is shown at the top. Direct regulation of the psmα and psmβ operons by AgrA is shown left (blue shadowing) and RNAIII-dependent Agr control of other target genes at the right (yellow shadowing). The likely evolution of the connection of quorum-sensing, RNAIII-dependent and –independent control is apparent in the encoding of the PSM δ-toxin (hld) by RNAIII. Agr also controls the psm-mec gene in an RNAIII-independent manner, but binding of AgrA to the psm-mec promoter has not yet been demonstrated.