Table 2. Activation of Receptor Tyrosine Kinases and downstream signaling proteins in splenic macrophages from hamsters infected with L. donovani.1 .
| Phosphoprotein (Entrez Gene Name) | Symbol | Fold Increase2 |
| v-akt murine thymoma viral oncogene homolog 1 | AKT1 | 20.7±12.1 |
| v-akt murine thymoma viral oncogene homolog 2 | AKT2 | 159.9±22.15 |
| EPH receptor A1 | EPHA1 | 7±3.95 |
| EPH receptor A3 | EPHA3 | 5.7±5.25 |
| EPH receptor B4 | EPHB4 | 4.9±0.3 |
| Fibroblast growth factor receptor 1 | FGFR1 | 2.1±0.35 |
| Fibroblast growth factor receptor 3 | FGFR3 | 2.7±0.3 |
| Insulin receptor substrate 1 | IRS1 | 40.2±16.3 |
| v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog | KIT | 4.4±3.55 |
| Mitogen-activated protein kinase 3 | MAPK3 | 2.1±1.65 |
| Neurotrophic tyrosine kinase, receptor, type 1 | NTRK1 | 4.7±2.15 |
| Neurotrophic tyrosine kinase, receptor, type 2 | NTRK2 | 1.9±0.95 |
| v-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (avian) | SRC | 152±23.1 |
| Signal transducer and activator of transcription 1 | STAT1 | 5.7±2.45 |
| Signal transducer and activator of transcription 3 | STAT3 | 2.4±0.85 |
| TEK tyrosine kinase, endothelial | TEK | 7.3±3.65 |
| zeta-chain (TCR) associated protein kinase 70 kDa | ZAP70 | 14±11.2 |
1
Determined using a PathScan Antibody Array (Chemiluniscent readout, Cell Signaling; 4 arrays per group) and analyzed with the IPA Software.
2
Fold-change (mean ± SEM) of the phosphoprotein expressed in splenic macrophages isolated from 28-day infected hamsters compared to splenic macrophages from uninfected hamsters.
RTKs and signaling proteins with a fold change >1.5 are shown.