Table 1. MicroRNAs most highly changed in expression, based on microarray, in joints of different mouse strains.
B6 | C3H | IL-10−/− | |||
miRNA | Fold Δ | miRNA | Fold Δ | miRNA | Fold Δ |
miR-146a | 5.67 | miR-146a | 10.8 | miR-21 | 6.08 |
miR-21 | 3.92 | miR-21 | 8.12 | miR-146a | 5.34 |
miR-706 | 3.47 | miR-142-3p | 6.54 | miR-155 | 5.12 |
miR-29b | 2.31 | miR-142-5p | 4.99 | miR-193b | −3.04 |
miR-715 | 2.24 | miR-34a | 4.4 | miR-150 | −2.56 |
miR-340-5p | 2.21 | miR-18a | 3.35 | miR-145 | −2.43 |
miR-34a | 2.16 | miR-19b | 3.08 | miR-181a | −2.37 |
miR-689 | 2.12 | miR-145 | −3.07 | miR-181b | −2.29 |
List of 8 most highly differentially expressed miRNAs in B. burgdorferi-infected joints of B6, C3H and B6 IL-10−/− mice at two weeks post-infection, based on Agilent mouse miRNA microarray. Shown is fold-change in expression compared to uninfected controls. Significance was determined using Welch's t-test with Benjamini and Hochberg correction (p<0.05, n = 3–4 mice per group).