Table 1.
Effect | Species | Drug |
Relaxation | Porcine | G-1[36,46] |
ICI182,780[35,36] | ||
Raloxifene[37] | ||
Tamoxifen[73] | ||
Rabbit | Raloxifene[54] | |
Tamoxifen[74] | ||
Endothelial NO production | Porcine | G-1[36] |
Raloxifene[54] | ||
Tamoxifen[74] | ||
CASMC BKCa channel opening | Porcine | G-1[46] |
Raloxifene[37] | ||
Tamoxifen[10] | ||
Human | G-1[46] | |
Inhibition of CASMC proliferation | Porcine | G-1[47] |
Human | G-1[47] | |
Inhibition of CASMC migration | Porcine | G-1[47] |
CASMC: Coronary artery smooth muscle cells; BKCa: G-1 opens calcium-activated potassium; NO: Nitric oxide.