Table 2.
Species | Drug | |
Coronary artery relaxation | ||
Endothelium-dependent, in vitro | Porcine | G-1[36] |
Rabbit | Raloxifen[54] | |
Tamoxifen[73,74] | ||
Endothelium-independent, in vitro | Porcine | G-1[46] |
Raloxifen[37] | ||
Reduced cardiac ischemic injury/infarct | Rat | G-1[75,76] |
Reduced cerebral ischemic injury/infarct | Mice | G-1[77] |
Middle cerebral artery relaxation, in vitro | Rat | G-1[78] |
Systemic artery relaxation, in vitro | Mice | G-1[40] |
G-1[49] | ||
G-1[50] | ||
G-1[79] | ||
Rat | G-1[51] | |
G-1[52] | ||
Human | G-1[50] | |
Reduced systemic blood pressure, infusion | Rats | G-1[49] |
G-1[50] | ||
Inhibit VSM cell proliferation | Porcine | G-1[47] |
Human | G-1[50] | |
Inhibit endothelial cell proliferation | Mice | G-1[70] |
Prevents calcium-induced increases in plasma cholesterol | Rats | G-1[80] |
VSM: Vascular smooth muscle.