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. 2014 Jun 17;106(6):dju118. doi: 10.1093/jnci/dju118

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Published by Oxford University Press 2014.

PMC Copyright notice

Figure 4. — Lung cancer incidences in each category of time to first cigarette (TTFC) and pack-years in the Environment and Genetics in Lung Cancer Etiology study (EAGLE). The figure shows the point estimate and 95% confidence interval of the absolute lung cancer rate per 100000 person-years (PY). The table under the figure shows the value of the point estimate (number of lung cancer case subjects). Incidence rates were estimated using a binomial linear model with 12 joint categories of TTFC and pack-years as well as the never smokers category. To evaluate whether the linear trend of lung cancer incidence with increased pack-years differed by TTFC statistically, we tested the interaction of TTFC and pack-years (treated as an ordinal variable) among smokers only. All statistical tests were two-sided.