Table I.
Effect of cavin-1 expression on proteins in PC3 EVs with reported roles in bone metastasis
| Accession | Protein name | Mean ratio (cavin-1:GFP) | No. of Obs | p |
|---|---|---|---|---|
| Decreased in cavin-1 EVs | ||||
| P05231 | Interleukin-6 | 0.1011 | 28 | 0.0063 |
| Q13253 | Noggin | 0.1575 | 2 | 0.00414 |
| P12110 | Collagen alpha-2(VI) chain | 0.262 | 3 | 0.00618 |
| P08476 | Inhibin beta A chain | 0.2396 | 30 | 0.00683 |
| P17936 | Insulin-like growth factor-binding protein 3 | 0.3655 | 2 | 0.03129 |
| P12109 | Collagen alpha-1(VI) chain | 0.4159 | 62 | 0.01493 |
| P08195 | 4F2 cell-surface antigen heavy chain | 0.4424 | 14 | 0.01487 |
| P00749 | Urokinase-type plasminogen activator | 0.4494 | 139 | 0.03151 |
| P29317 | Ephrin type-A receptor 2 | 0.527 | 11 | 0.02467 |
| P04080 | Cystatin-B | 0.5346 | 27 | 0.0169 |
| P02751 | Fibronectin | 0.567 | 4 | 0.14112 |
| P61812 | Transforming growth factor beta-2 | 0.5858 | 55 | 0.01978 |
| Increased in cavin-1 EVs | ||||
| P18065 | Insulin-like growth factor-binding protein 2 | 3.9048 | 4 | 0.00605 |
| P00750 | Tissue-type plasminogen activator | 2.0035 | 6 | 0.03213 |
| No change in cavin-1 EVs | ||||
| Q15828 | Cystatin-M | 0.63017 | 6 | 0.23465 |
| O94907 | Dickkopf-related protein 1 | 0.73475 | 8 | 0.58905 |
| Q02809 | Procollagen-lysine,2-oxoglutarate 5-dioxygenase 1 | 0.79309 | 22 | 0.80976 |
| P01034 | Cystatin-C | 0.82386 | 22 | 0.87766 |
| O00469 | Procollagen-lysine,2-oxoglutarate 5-dioxygenase 2 | 1.02675 | 4 | 0.97971 |