Table 2.
Selected genes enriched for GWAS associations relative to their length
| Chromosome | Position (Mb, GR37) | Gene | Associated phenotypes (P <1E − 5), ordered from most significant to least |
|---|---|---|---|
| 1 | 72.31 | NEGR1 | BMI, tPA, Crohn’s disease, Hypertension, total cholesterol change with statins, SLE |
| 2 | 43.64 | THADA | Polycystic ovary syndrome, Crohn’s disease, PLT, T2D, Prostate cancer, Cleft lip, Hair morphology, FBG |
| 3 | 41.65 | ULK4 | Blood pressure, multiple myeloma, pulse pressure, intelligence, alcohol dependence, bipolar disorder |
| 4 | 9.97 | SLC2A9 | Uric acid/gout, esophageal cancer, narcolepsy, AD with psychotic symptoms |
| 6 | 20.88 | CDKAL1 | T2D, Cystatin C, Creatinine, Crohn’s disease, Selective IgAD, Insulin response, IBS, Stroke, UACR, Rectal cancer, Idiopathic scoliosis |
| 6 | 152.22 | ESR1 | Height, T2D, MI, bone mineral density, MDD, HDL cholesterol, alcohol dependence, endometriosis |
| 8 | 3.82 | CSMD1 | CAD, psoriasis, schizophrenia, longevity, statin-induced myopathy, HDL cholesterol, HbA1C, post-operative nausea, T2D, LDL cholesterol, HOMA-IR, microalbumineria, weight, PD, cisplatin IC50, MS, alpha-linoleic acid, MDD, Digit span, MCHC, Melanoma, gamma-tocopherol, Height, late-onset AD, asthma, percent body fat, narcotic addiction |
| 9 | 9.46 | PTPRD | Psoriasis, restless leg syndrome, T2D, azoospermia, hearing at 125 Hz, Paclitaxel IC50, asthma, stroke, osteoarthritis, creatnine, lung cancer, HDL cholesterol, metformin response, homocysteine, neutrophil count, partial epilepsy, MS severity |
| 9 | 16.64 | BNC2 | Ovarian cancer, freckles, HbA1C in T1D, paclitaxel IC50, LDL cholesterol, retina complications in T1D, total cholesterol |
| 9 | 136.14 | ABO | vWF, ICAM-1, metabolic syndrome, E-selectin, TNF-a, ALP, venous thrombosis, LDL cholesterol, total cholesterol, T1D, VLDL cholesterol, Phytosterol, ACE activity, MI, pancreatic cancer, MCHC, CAD, Grave’s disease, D-dimer, Simpson–Angus scale |
| 16 | 6.92 | RBFOX1 | BMI, lung cancer, dengue shock syndrome, Combined T2D/HTN/CAD case status, anti-depressant treatment outcomes and side effects, asthma, restless leg syndrome, hearing, bipolar disorder, ALL, schizophrenia, MS in females, vitamin D, triglycerides, parent rating scale in ADHD and conduct disorder |
| 16 | 10.06 | GRIN2A | Chronic hepatitis B progression, PD, Rheumatoid arthritis (CCP-positive), HIV-1 progression, adiponectin |
| 16 | 83.25 | CDH13 | Adiponectin, nicotine dependence, blood pressure, prostate cancer, paclitaxel IC50, CAD, clozapine effect on triglycerides, depression scale test, cognitive tests, stroke, extraversion, MCH, BMI, height, schizophrenia, fasting insulin, Narcolepsy, post-operative nausea, ADHD, ulcerative colitis, RBC |
| 17 | 43.81 | CRHR1 | PSP, PD, bone mineral density |
| 17 | 44.04 | MAPT | PSP, PD, primary biliary cirrhosis, BMI, lung function |
| 17 | 44.21 | KIAA1267 | PD, PSP, ADHD, autism, lung function |
Traits with P < 5E − 8 are bolded. ACE, angiotensin converting enzyme; AD, Alzheimer’s disease; ADHD, attention-deficit hyperactivity disorder; ALL, acute lymphoblastic leukemia; ALP, alkaline phosphatase; BMI, body mass index; CAD, coronary artery disease; FBG, fasting blood glucose; HbA1C, glycated hemoglobin; HTN, hypertension; MDD, major depressive disorder; MCH, mean corpuscular hemoglobin; MI, myocardial infarction; MS, multiple sclerosis; PD, Parkinson’s disease; PLT, platelet count; PSP, progressive supranuclear palsy; RBC, red blood cell count; SLE, systemic lupus erythematosus; tPA, tissue plasminogen activator; T1D, Type 1 diabetes; T2D, Type 2 diabetes