Table 3.

Details of the 10 most heritable probes that do not contain any annotated SNPs

Probe ID	Chr	CpG position	h 2	Genomic context	Type	HIL	#CpG	GWAS SNP	SNP position	P value
cg15671450	6	29895116	0.934	Upstream (HCG4B)	II	HC	1	rs111482415	29923140	4.8 × 10-78
cg01903420	13	27295928	0.933	Intergenic	II	IC	2	rs1374010	27295317	3.0 × 10-105
cg03168497	17	48586147	0.932	Intronic (MYCBPAP)	II	HC	4	rs73351675	48585554	8.1 × 10-84
cg11064039	7	766100	0.932	Intronic (PRKAR1B)	I	HC	3	rs11763218	852281	8.8 × 10-58
cg24372256	21	43528868	0.931	Intronic (UMODL1)	II	IC	1	rs34212454	43529216	2.9 × 10-101
cg26764761	16	87682142	0.927	Intronic (JPH2)	I	IC	7	rs748554	87682775	1.4 × 10-107
cg16761754	14	105127242	0.927	Intergeneic	I	IC	3	rs4075355	105125512	1.8 × 10-77
cg21358336	17	6558440	0.927	Upstream (MIR4520B)/Downstream (MIR4520A)	II	ICshore	1	rs2040847	6558011	1.3 × 10-91
cg04118610	4	62707027	0.926	Intronic (LPHN3)	II	LC	2	rs10021525	62707476	2.1 × 10-105
cg08164151	12	131118432	0.925	Intergeneic	II	IC	3	rs10848167	131123623	2.9 × 10-101

Genomic context of probes was annotated using ANNOVAR [24], with a probe being upstream or downstream defined as being within 2 KB of the transcription start site or transcription end site, respectively.

GWAS SNP = Most significant SNP from GWAS; HIL = ‘HIL’ classification of CpG [22]; Type = Illumina HumanMethylation450 assay probe type.