Table 1.
Survival rates of mice after lethal virus challenge§
| Vaccine |
Survival rates (No. of survivors/No. tested) |
|||
|---|---|---|---|---|
| One dose | Two doses | Three doses | Four doses | |
| M04 |
13/16 (81.3%)a,b |
15/16 (93.8%)a,b |
16/16 (100%)a,b |
16/16 (100%)a,b |
| M84 |
12/16 (75%)a,b |
16/16 (100%)a,b |
16/16 (100%)a,b |
16/16 (100%)a,b |
| M105 |
5/16 (31.3%)a |
6/16 (37.5%)a |
8/16 (50%)a |
10/16 (62.5%)a |
| IE-1 |
11/16 (68.8%)a,b |
14/16 (87.5%)a,b |
16/16 (100%)a,b |
16/16 (100%)a,b |
| M55 |
0/16 (0%) |
0/16 (0%) |
9/16 (56.3%)a |
10/16 (62.5%)a |
| Control | 0/16(0%) | |||
§Mice were immunized 1 ~ 4 times, at an interval of 2 weeks, with 100 μg plasmid DNAs. Two weeks after the final immunization, mice were challenged with a lethal dose (3 × LD50) of SG-MCMV. The survival rates of mice were determined 21 days postinfection.
aSignificant difference compared with control animals, P < 0.05.
bSignificant difference compared with the M55 group at the same immunization frequency.