Figure 1.

PDE9A does not contribute to the ERG under scotopic conditions. For all figures, WT is drawn in black and KO in red. Also for all figures, data are plotted as average ±s.e.m. When the s.e.m. cannot be seen, it is smaller than the symbol. (A,B) Representative responses to increasing light intensities (0.2– 600 R^*/rod) from age matched WT (A) and PDE9A KO (B) retinas. (C) Average b-wave amplitudes vs. flash intensity for WT (black squares; 16–22 records) and KO (red diamonds; 18–28 records) mice. (D) Illustration of the parameters used to characterize the kinetics of the b-wave. Stimulus onset is designated by an upward black arrow, 66% of the peak amplitude is indicated by the blue line and 50% by the green line. Time taken by the b-wave to rise from the stimulus onset to 66% of its peak amplitude (left dashed blue arrow) or to 50% of its amplitude (left dashed green arrow) were used for comparison of its kinetics. Time taken by the b-wave to fall to 66 or 50% of its peak amplitude is indicated by the right blue and green arrows. (E) Times taken by the b-wave to rise (triangles) and fall (squares) to 66% of its amplitude, and the duration between them (width, circles) at the measured intensities.