Figure 3.
Absence of PDE9A slows the falling phase of the b-wave of a saturating flash under photopic conditions. (A) Average responses of WT and KO retinas to a saturating flash (1000 scot cd s m−2) after 2 s light adaptation. The responses to both the first and second saturating flashes (presented before and after stimulation with UV and green light, respectively) in each retina were averaged. (B) Response amplitudes of the a- and b-waves at the saturating flash are reduced in KO (13 WT and 14 KO mice). (C) The times taken by the b-wave to rise and fall to 66% of its amplitude and the duration between them. (D,E) Average response of WT and KO retinas to the first (1) and second (2) saturating flash. (F) The width of the b-wave at 50% of its amplitude for the first (1) and second (2) saturating flashes increased in KO.