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Pharmacokinetic parameter of cT84.66 following IV or SC administration to mice calculated by noncompartmental analysis (n = 4)
| Parameters | IV 1 mg/kg | SC 1 mg/kg | SC 10 mg/kg |
|---|---|---|---|
| tmax (h) | 1.0 | 36 | 36 |
| Cmax (µg/mL) | 13.2 ± 3.7 | 3.8 ± 0.6 | 29.9 ± 10.4 |
| AUC0-t (µg·h/mL) | 540.2 ± 175.4 | 530.4 ± 99.5 | 3401.3 ± 513.9 |
| AUC0-∝ (µg·h/mL) | 575.0 ± 197.0 | 592.4 ± 161.4 | 3456.1 ± 549.4 |
| t1/2 (h) | 73.0 ± 19.7 | 77.4 ± 34.6 | 45.4 ± 7.1 |
| CL (mL/h/kg) | 2.0 ± 0.7 | 1.9 ± 0.4 | 3.0 ± 0.5 |
