Table 4. Protein concentration and gene expression of inflammatory and regulatory mediators in the colon of untreated piglets and DSS-treated piglets that were or not fed MCM.
Treatment |
|||
---|---|---|---|
NEG | POS | MCM | |
Protein, pg/g tissue | |||
TNF-α | 291 ± 8# | 478 ± 56* | 413 ± 30* |
IL-6 | 16 ± 2# | 26 ± 2* | 19 ± 2# |
Gene Expression, -fold of NEG | |||
IL-1β | 1.0 ± 0.2 | 0.9 ± 0.4 | 0.2 ± 0.0*# |
IL-6 | 1.0 ± 0.1# | 4.1 ± 1.4* | 1.1 ± 0.1# |
IL-17 | 1.0 ± 0.2 | 0.6 ± 0.2 | 0.2 ± 0.0*# |
TNF-α | 1.0 ± 0.3# | 1.6 ± 0.4 | 0.4 ± 0.0*# |
Data are mean ± SEM. N=3; Means in a row superscripts with “*” differ significantly from NEG and those with “#” differ significantly from POS; P<0.05. NEG, negative control; POS, DSS positive control; MCM, DSS positive with MCM treatment. DSS, dextran sodium sulfate.